Differences in views of experts about their role in particulate matter policy advice: Empirical evidence from an international expert consultation

There is ample scientific evidence of adverse health effects of air pollution at exposure levels that are common among the general population. Some points of uncertainty remain, however. Several theories exist regarding the various roles that experts may play when they offer policy advice on uncertain issues such as particulate matter (PM). Roles may vary according to e.g. the views of the expert on the science-policy interface or the extent to which she/he involves stakeholders. Empirical underpinning of these theories, however, does not exist. We therefore conducted a consultation with experts on the following research question: What are PM experts’ views on their roles when providing policy advice? Q methodology was used to empirically test theoretical notions concerning the existence of differences in views on expert roles. Experts were selected based on a structured nominee process. In total, 31 international PM experts participated. Responses were examined via Principal Component Analysis, and for the open-ended questions, we used Atlas.ti software. Four different expert roles were identified among the participating experts. Main differences were found with respect to views on the need for precautionary measures and on the experts positioning within the science-policy interface. There was consensus on certain issues such as the need for transparency, general disagreement with current policies and general agreement on key scientific issues. This empirical study shows that while most PM experts consider their views on the risks of PM to be in line with those of their colleagues, four distinct expert roles were observed. This provides support for thus far largely theoretical debates on the existence of different roles of experts when they provide policy advice

Behavior change interventions: the potential of ontologies for advancing science and practice

A central goal of behavioral medicine is the creation of evidence-based interventions for promoting behavior change. Scientific knowledge about behavior change could be more effectively accumulated using "ontologies." In information science, an ontology is a systematic method for articulating a "controlled vocabulary" of agreed-upon terms and their inter-relationships. It involves three core elements: (1) a controlled vocabulary specifying and defining existing classes; (2) specification of the inter-relationships between classes; and (3) codification in a computer-readable format to enable knowledge generation, organization, reuse, integration, and analysis. This paper introduces ontologies, provides a review of current efforts to create ontologies related to behavior change interventions and suggests future work. This paper was written by behavioral medicine and information science experts and was developed in partnership between the Society of Behavioral Medicine's Technology Special Interest Group (SIG) and the Theories and Techniques of Behavior Change Interventions SIG. In recent years significant progress has been made in the foundational work needed to develop ontologies of behavior change. Ontologies of behavior change could facilitate a transformation of behavioral science from a field in which data from different experiments are siloed into one in which data across experiments could be compared and/or integrated. This could facilitate new approaches to hypothesis generation and knowledge discovery in behavioral science

Expert Views on Their Role as Policy Advisor: Pilot Study for the Cases of Electromagnetic Fields, Particulate Matter, and Antimicrobial Resistance

This perspective presents empirical data to demonstrate the existence of different expert views on scientific policy advice on complex environmental health issues. These views are partly research-field specific. According to scientific literature, experts differ in the way they provide policy advice on complex issues such as electromagnetic fields (EMF), particulate matter (PM), and antimicrobial resistance (AMR). Where some experts feel their primary task is to carry out fundamental research, others actively engage in the policy dialogue. Although the literature provides ideas about expert roles, there exists little empirical underpinning. Our aim is to gather empirical evidence about expert roles. The results of an international study indicated that experts on EMF, PM, and AMR differ in the way they view their role in the policy dialogue. For example, experts differed in their views on the need for precaution and their motivation to initiate stakeholder cooperation. Besides, most experts thought that their views on the risks of EMF/PM/AMR did not differ from those of colleagues. Great dissensus was found in views on the best ways of managing risks and uncertainties. In conclusion, the theoretical ideal-typical roles from the literature can be identified to a certain extent

Understanding a national increase in COVID-19 vaccination intention, the Netherlands, November 2020-March 2021

The intention to get the COVID-19 vaccine increased from 48% (November 2020) to 75% (March 2021) as national campaigning in the Netherlands commenced. Using a mixed method approach we identified six vaccination beliefs and two contextual factors informing this increase. Analysis of a national survey confirmed that shifting intentions were a function of shifting beliefs: people with stronger intention to vaccinate were most motivated by protecting others and reopening society; those reluctant were most concerned about side effects

Roles of scientists as policy advisers on complex issues: A literature review

Background and Aims: Policymakers frequently encounter complex issues, and the role of scientists as policy advisers on these issues is not always clearly defined. We present an overview of the interdisciplinary literature on the roles of scientific experts when advising policymakers on complex issues, and in particular on the factors that influence these roles. / Methods: A structured literature search was combined with literature found in reference lists of peer reviewed papers (the snowball method). In total, 267 publications were analyzed using scientometrics analyses (discipline clustering analysis and co-citation analysis) followed by a qualitative analysis and interpretation. / Results: The scientometrics analysis shows an amalgam of disciplines that publish on our research topic. Five clusters of authors were identified based on similarities in the references used: post-normal science, science and technology studies, science policy studies, politics of expertise and risk governance. The content of the clusters demonstrates that authors in different clusters agree that the role of experts is influenced by the type of problem (simple or complex) and by other parties (the public and stakeholders). However, opinions vary on the extent to which roles can vary and the necessity to explicate different viewpoints. / Discussion and conclusions: Publications on scientific experts who provide policy advice affirm that such experts should and do hold different roles, depending on the type of problem and factors such as values held by the expert and the type of knowledge. We conclude that research on expert roles has remained mostly theoretical. Existing theories about science systems can be used to study real policy advice processes. Most theories are well elaborated, but empirical proof for the described changes, roles and processes is limited

SALL4 controls cell fate in response to DNA base composition

Contains fulltext : 232790.pdf (Publisher’s version ) (Open Access

Viruses: incredible nanomachines. New advances with filamentous phages

During recent decades, bacteriophages have been at the cutting edge of new developments in molecular biology, biophysics, and, more recently, bionanotechnology. In particular filamentous viruses, for example bacteriophage M13, have a virion architecture that enables precision building of ordered and defect-free two and three-dimensional structures on a nanometre scale. This could not have been possible without detailed knowledge of coat protein structure and dynamics during the virus reproduction cycle. The results of the spectroscopic studies conducted in our group compellingly demonstrate a critical role of membrane embedment of the protein both during infectious entry of the virus into the host cell and during assembly of the new virion in the host membrane. The protein is effectively embedded in the membrane by a strong C-terminal interfacial anchor, which together with a simple tilt mechanism and a subtle structural adjustment of the extreme end of its N terminus provides favourable thermodynamical association of the protein in the lipid bilayer. This basic physicochemical rule cannot be violated and any new bionanotechnology that will emerge from bacteriophage M13 should take this into account